| Title (priority date): |
| Reference: |
1-32764/FMI |
| Inventors: |
Bichsel, Hemmings, Stegert and Tamaskovic |
| Description: |
The inventors have characterized the regulation of NDR by phosphorylation of two regulatory residues Ser281 and Thr444, and its activation through a direct interaction with EF-hand Ca2+-binding proteins of the S100 family. As a result, they uncovered an additional regulatory phosphorylation site on NDR1, Thr74. |
| Applications: |
Screen identifying modulators of Ndr kinase activity. |
| Status: |
Pending EP, JP and US |
| Opportunity: |
Non exclusive license available |
| Publications: |
Bischel et al., J Biol Chem. 2004 Aug 20;279(34):35228-35 |
| Contact: |
Dr. Nicolas Favre, tel: +41 61 6978382, e-mail: nicolas.favre@fmi.ch |
| PCT File: |
WO04048576 |
