| Title (priority date): |
| Reference: |
1-32998/FMI |
| Inventors: |
Badache, Hynes and Marone |
| Description: |
Myc-CGI-27 was expressed in vitro in reticulocyte lysates and tested for binding. Immunodepletion of endogenous Shc from the lysates led to strongly decreased binding of Myc-CGI-27 to phospho-YD. |
| Applications: |
The use of a modulator of a mediator of ErbB2-dependent cell motility (MEMO) polypeptide or an homolog of this is claimed, for modulating cellular migration. Also claimed are a method of screening for modulators of cellular migration or binding partners of MEMO, an isolated MEMO polypeptide, a vector comprising a nucleic acid encoding MEMO, methods for preparing a polypeptide, si RNA duplexes and a transgenic non-human mammal, a transformed host cell, a nucleic acid, a double stranded RNA, a siRNA duplex, further vectors, a transgenic non-human mammal, an isolated antibody, and a MEMO inhibitor. It is claimed that modulators of MEMO are useful for inhibiting metastasis and/or angiogenesis in cancer and for promoting wound healing. The invention as claimed provides a means of contolling angiogenesis and cellular migration. |
| Status: |
Pending EP, JP and US |
| Opportunity: |
Exclusive and non exclusive license available |
| Publications: |
Marone et al., Nat Cell Biol. 2004 Jun;6(6):515-22 |
| Contact: |
Dr. Nicolas Favre, tel: +41 61 6978382, e-mail: nicolas.favre@fmi.ch |
| PCT File: |
WO04083865 |
