| Title (priority date): |
| Reference: |
1-32130/FMI |
| Inventors: |
Ackermann and Matus |
| Description: |
Methods and materials for use in markers of synaptic activity and use of these for identifying modulators of such activity. the inventors showed that activation of NMDA receptors produced long-duration Ca2+-dependent targeting of profilin II to spine heads. |
| Applications: |
A method for identifying or detecting a synapse that has been activated, or assessing the level of activation of a synapse, which method comprises:
(i) determining the presence and\or amount in a morphologically specialised postsynaptic site in the synapse of a detectable cellular component associated with the activation, and
(ii) correlating the result of the determination with synaptic activation. |
| Status: |
Pending EP |
| Opportunity: |
Exclusive or non exclusive license available |
| Publications: |
Ackermann et al., Nat Neurosci. 2003 Nov;6(11):1194-200 |
| Contact: |
Dr. Nicolas Favre, tel: +41 61 6978382, e-mail: nicolas.favre@fmi.ch |
| PCT File: |
WO03014733 |
