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| HELGE GROSSHANS |
| Mechanisms of microRNA-mediated gene regulation in animal development |
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MicroRNAs (miRNAs) are a large and important class of regulatory RNAs that silence target mRNAs through an antisense mechanism. They function in diverse developmental processes, such as apoptosis and cell differentiation, and their dysregulation has been implicated in various diseases, particularly cancer. Despite such critical roles, deciphering the mechanisms of miRNA-mediated RNA silencing has been difficult and has led to multiple, partially contradictory models. Moreover, adding additional layers of complexity, miRNAs themselves are the subject of extensive regulation by mechanisms that are only beginning to emerge.
We use the roundworm Caenorhabditis elegans as a model system to investigate how miRNAs function and how they are themselves regulated in vivo. C. elegans is the organism in which miRNAs and many components of the miRNA machinery were originally discovered. We are exploiting the powerful genetics and cell biology tools of C. elegans to identify novel miRNA pathway genes. Subsequent biochemical characterization of these novel factors reveals their molecular functions. Our combination of genetic and biochemical approaches in a single experimental system permits the generation of physiologically relevant, mechanistic insights into the function and regulation of miRNAs. |
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For further information, please contact
Administrative Assistant Gabi Gruber
(+41 61 6976580) |
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