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| BRIAN A. HEMMINGS |
| Molecular aspects of protein phospho-
rylation and signal transduction |
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| Judging simply by the abundance of protein
kinase and protein phosphatase genes,
protein phosphorylation is a very important
regulatory mechanism. Our current work
focuses on the role of these enzymes in
eukaryotic signalling pathways and their possible implications in human diseases. Signal
transduction pathways in mammalian cells
function through the coordinated activation,
or inactivation of protein kinases and phosphatases localised in the cell membrane,
cytoplasm or nucleus. Many human diseases
result from deregulation of signal transduction pathways; for example, the proliferation
signal pathways of cancer cells are permanently upregulated following mutation of key
regulatory enzymes. |
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For further information, please contact
Administrative Assistant Isabella Bogdal
(+41 61 6976653) |
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To contact FMI members directly, click
here for the FMI Directory. |
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