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| NANCY HYNES |
| The ErbB receptor tyrosine kinase
family as signal integrators |
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| It is important that extracellular signals are
correctly interpreted to achieve proper
developmental or proliferative responses
and avoid malignant growth. Receptors
of the tyrosine kinase family, in particular
the epidermal growth factor receptor (ErbB)
family, play pivotal roles in this process.
Binding to specific peptide ligands, they integrate external stimuli with internal signal
transduction pathways. ErbB1-4 are expressed in tissues of epithelial, mesenchymal
and neuronal origin. Deregulated expression of ErbB receptors, in particular ErbB1
and ErbB2, is implicated in the development
of human cancers, including breast, lungs
and ovaries. We examine normal activation
of these receptors, characterise their roles in
tumour growth, and target them with growth inhibitory antibodies or chemical inhibitors
to interfere with their oncogenic activity. We
also study cross-regulation between ErbB
receptors, as signal integrators, and the
cytokine receptor superfamily, including the
receptors for prolactin and IL6. |
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For further information, please contact
Administrative Assistant Isabella Bogdal
(+41 61 6976653) |
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To contact FMI members directly, click
here for the FMI Directory. |
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