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| NICOLAS THOMÄ |
| Structural tumour biology |
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| A major hallmark of cancer cells is their inherent genomic instability. Incomplete DNA repair and replication initiate tumours and in addition accelerate the malignant transformation process. Surprisingly, the machinery responsible for DNA maintenance is also intricately involved in defense against accelerated aging. Our focus is on pre-mature aging syndromes tightly linked to cancer and genomic instability. The protein complexes studied are involved in crucial cellular functions such as signaling cascades, telomere maintenance and DNA repair. X-ray crystallography combined with biochemical and biophysical techniques will be used to elucidate the structure and molecular workings of these macromolecular machines. This work is expected to shed light on fundamental biological processes, while at the same time providing novel therapeutic strategies for combating cancer and age-related ailments. |
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For further information, please contact
Administrative Assistant Keri Jane Shilling
(+41 61 6976651) |
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here for the FMI Directory. |
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