| |
| YOSHIKUNI NAGAMINE |
| Signal transduction and the plasminogen
activator system |
 |
| The plasminogen activator (PA) system plays
an important role in processes involving extracellular proteolysis, such as angiogenesis,
wound healing, gametogenesis, inflammation
and tumour metastasis. Recent results show
a new form of biological regulation by the
PA system not involving proteolytic activity in
which urokinase-type PA (uPA)-occupied uPA
receptor acquires a high affinity for vitronectin, promoting cell adhesion or migration
on vitronectin-containing extracellular matrix.
Studying regulation of uPA and PA inhibitor-1
by growth factors, we found serine/threonine
phosphorylation of the adaptor/docking protein ShcA. Tyrosine phosphorylation of ShcA
and its role in signalling have been well documented, but its serine/threonine phosphorylation has been little studied. Our work has
revealed a role for serine phosphorylation of
ShcA in insulin induced signalling. |
| |
For further information, please contact
Administrative Assistant Gabi Gruber
(+41 61 6976580) |
| |
To contact FMI members directly, click
here for the FMI Directory. |
| |
|
|
|
|
